Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic …
S El-Kalyoubi, MM Khalifa, MT Abo-Elfadl… - Journal of enzyme …, 2023 - Taylor & Francis
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
Pyrimidine-based dual-target inhibitors targeting epidermal growth factor receptor for overcoming drug resistance in cancer therapy (2006-present)
Y An, X Lv, S Xu, H Li, P Zheng, W Zhu… - European Journal of …, 2025 - Elsevier
The epidermal growth factor receptor (EGFR) is a pivotal member of the epidermal growth
factor receptor family, exerting crucial regulatory influence on cellular physiological …
factor receptor family, exerting crucial regulatory influence on cellular physiological …
Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and …
Herein, we envisioned the design and synthesis of novel pyrazolopyrimidines (confirmed by
elemental analysis, 1 H and 13 C NMR, and mass spectra) as multitarget-directed drug …
elemental analysis, 1 H and 13 C NMR, and mass spectra) as multitarget-directed drug …
Discovery of pyran annulated heterocyclic scaffolds linked to carboxamide fragments: Anticancer evaluation, topoisomerase I/II, tyrosine kinase receptor inhibition and …
AM Fouda, RA El-Eisawy, MAA El-Nassag… - Journal of Molecular …, 2024 - Elsevier
A class of 4H-benzo [h] chromene (4a-h) and 1H-benzo [f] chromene (6a-h) derivatives
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …
linked to carboxamide/carbothioamide at the 3/2-positions were designed and synthesized …
Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer─ Design, Synthesis, and In Vitro Evaluation
The epidermal growth factor receptor (EGFR) is vital for regulating cellular functions,
including cell division, migration, survival, apoptosis, angiogenesis, and cancer. EGFR …
including cell division, migration, survival, apoptosis, angiogenesis, and cancer. EGFR …
Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4 (5H)-ones as potential apoptotic inducers targeting wild …
A novel series of ethylidenehydrazineylthiazol-4 (5H)-ones were synthesized using various
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of …
Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers
Aim: Our objective was to design and synthesize a new range of pyrazolopyrimidines while
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & …
Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl) thio) acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro …
In this work, additional effort was applied to design new BIBR1532-based analogues with
potential inhibitory activity against telomerase and acting as multitarget antitumor candidates …
potential inhibitory activity against telomerase and acting as multitarget antitumor candidates …
Symbiotic Antidiabetic Effect of Lactobacillus casei and the Bioactive Extract of Cleome droserifolia (Forssk.) Del. on Mice with Type 2 Diabetes Induced by Alloxan
AIA El Maksoud, AA Al‐Karmalawy… - Chemistry & …, 2024 - Wiley Online Library
The consumption of probiotics protects pancreatic β‐cells from oxidative damage, delaying
the onset of type 2 diabetes mellitus (T2DM) and preventing microvascular and …
the onset of type 2 diabetes mellitus (T2DM) and preventing microvascular and …
[HTML][HTML] In Silico Exploration of Novel EGFR Kinase Mutant-Selective Inhibitors Using a Hybrid Computational Approach
MAA Noor, MM Haq, MAR Chowdhury, H Tayara… - Pharmaceuticals, 2024 - mdpi.com
Targeting epidermal growth factor receptor (EGFR) mutants is a promising strategy for
treating non-small cell lung cancer (NSCLC). This study focused on the computational …
treating non-small cell lung cancer (NSCLC). This study focused on the computational …