In 2004, the US Food and Drug Administration (FDA) released an important report entitled
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …

Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular
Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and …

Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4)-linked d-
glucosamine and N-acetyl-d-glucosamine. It is one of the major cationic polymers and the …

RNA interference (RNAi) quietly crept into biological research in the 1990s when
unexpected gene-silencing phenomena in plants and flatworms first perplexed scientists …

Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids
over the past two decades. Many previous studies have demonstrated that synthetic delivery …

1.1. General Strategies in the Design of Tumor Targeted Therapeutics. Today's quest for
developing tumor-targeted therapies has naturally followed two nonoverlapping strategies …

Gene therapy provides great opportunities for treating diseases from genetic disorders,
infections and cancer. To achieve successful gene therapy, development of proper gene …

Cationic polymers are the subject of intense research as non-viral gene delivery systems,
due to their flexible properties, facile synthesis, robustness, and proven gene delivery …

A number of human diseases stem from defective genes. One approach to treating such
diseases is to replace, or override, the defective genes with normal genes, an approach …

RNA interference (RNAi) has become the method of choice to suppress gene expression in
vitro. It is also emerging as a powerful tool for in vivo research with over 90 studies …