To investigate whether the tumor suppressor gene PTEN affects the activity of the androgen
receptor (AR), we monitored the expression of the apoptotic gene HA-Bax (inserted in an …

Ligands for the nuclear receptor superfamily control many aspects of biology, including
development, reproduction, and homeostasis, through regulation of the transcriptional …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

The classical action of androgen receptor (AR) is to regulate gene transcriptional processes
via AR nuclear translocation, response element binding and recruitment of, or crosstalk with …

Background Prostate cancer continues to be the most common lethal malignancy diagnosed
in American men and the second leading cause of male cancer mortality. The American …

The androgen receptor (AR) is a critical effector of prostate cancer development and
progression. The dependence of this tumor type on AR activity is exploited in treatment of …

The androgen receptor (AR) is essential for the growth of prostate cancer cells. Here, we
report that tyrosine phosphorylation of AR is induced by growth factors and elevated in …

The glucocorticoid receptor (GR) belongs to the superfamily of ligand-activated transcription
factors, the nuclear hormone receptors. Like other members of the family, the GR possesses …

Given the role of the EGFR/HER2 family of tyrosine kinases in breast cancer, we dissected
the molecular basis of EGFR/HER2 kinase signaling in prostate cancer. Using the small …

Intrinsically disordered proteins, which do not adopt well-defined structures under
physiological conditions, are implicated in many human diseases. Small molecules that …