Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine

Y Xin, K Li, M Huang, C Liang, D Siemann, L Wu, Y Tan… - Oncogene, 2023 - nature.com
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Experimental tools and emerging principles of organellar mechanotransduction

K Li, YN Jan - Trends in Cell Biology, 2025 - cell.com
Mechanotransduction is the process by which cells detect mechanical forces and convert
them into biochemical or electrical signals. This process occurs across various cellular …

YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer

M Huang, H Wang, C Mackey, MC Chung… - International Journal of …, 2023 - mdpi.com
Biomechanical forces are of fundamental importance in biology, diseases, and medicine.
Mechanobiology is an emerging interdisciplinary field that studies how biological …

[HTML][HTML] Mechanism of static loading injury in human skeletal muscle cells

Y Yuan, H Zhang, YF Li, XN Xue… - American Journal of …, 2024 - ncbi.nlm.nih.gov
Objective: To establish a cellular-level mechanical injury model for human skeletal muscle
cells and investigate changes in the mechanical effect mechanism after such injuries …

Functional Interrogation of Ca2+ Signals in Human Cancer Cells In Vitro and Ex Vivo by Fluorescent Microscopy and Molecular Tools

C Liang, M Huang, M Tanaka, S Lightsey… - Microfluidic Systems for …, 2023 - Springer
Genetically encoded calcium indicators (GECIs) and high-resolution confocal microscopy
enable dynamic visualization of calcium signals in cells and tissues. Two-dimensional and …