[HTML][HTML] Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease

N Hirokawa, S Niwa, Y Tanaka - Neuron, 2010 - cell.com
The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Kinesin superfamily motor proteins and intracellular transport

N Hirokawa, Y Noda, Y Tanaka, S Niwa - Nature reviews Molecular cell …, 2009 - nature.com
Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

Genome-wide analyses identify KIF5A as a novel ALS gene

A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri… - Neuron, 2018 - cell.com
To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 …

Light-emitting diodes based on conjugated polymers

JH Burroughes, DDC Bradley, AR Brown, RN Marks… - nature, 1990 - nature.com
CONJUGATED polymers are organic semiconductors, the semiconducting behaviour being
associated with the π molecular orbitals delocalized along the polymer chain. Their main …

Kinesin and dynein superfamily proteins and the mechanism of organelle transport

N Hirokawa - Science, 1998 - science.org
Cells transport and sort proteins and lipids, after their synthesis, to various destinations at
appropriate velocities in membranous organelles and protein complexes. Intracellular …

Bead movement by single kinesin molecules studied with optical tweezers

SM Block, LSB Goldstein, BJ Schnapp - Nature, 1990 - nature.com
KINESIN, a mechanoenzyme that couples ATP hydrolysis to movement along microtubules,
is thought to power vesicle transport and other forms of microtubule-based motility1–6. Here …

Force and velocity measured for single kinesin molecules

K Svoboda, SM Block - Cell, 1994 - cell.com
We measured the force-velocity curves of single kinesin molecules attached to silica beads
movlng In an in vltro motility assay. Optical trapping interferometry was used to track …

Traffic control: regulation of kinesin motors

KJ Verhey, JW Hammond - Nature reviews Molecular cell biology, 2009 - nature.com
Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move
along the surface of, or destabilize, microtubule filaments. Much progress has been made in …

Analysis of the kinesin superfamily: insights into structure and function

H Miki, Y Okada, N Hirokawa - Trends in cell biology, 2005 - cell.com
Kinesin superfamily proteins (KIFs) are key players or 'hub'proteins in the intracellular
transport system, which is essential for cellular function and morphology. The KIF …

Movement of microtubules by single kinesin molecules

J Howard, AJ Hudspeth, RD Vale - Nature, 1989 - nature.com
Kinesin is a motor protein that uses energy derived from ATP hydrolysis to move organelles
along microtubules. Using a new technique for measuring the movement produced in vitro …