Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Artificial metalloenzymes combine the advantages of both natural enzymes and chemically
synthesized models, which have achieved significant progress in the last decade. This …

Diesel engines have advantages due to their potential for high fuel conversion efficiency.
However, it is necessary to reduce pollutant emissions, particularly NOx and soot to meet …

Highlights•Use of noncanonical amino acid (ncAAs) in therapeutics requires careful
evaluation.•NcAA-mediated strategies enable important routes to precisely defined …

Dynamic control over protein function is a central challenge in synthetic biology. To address
this challenge, we describe the development of an integrated computational and …

Metal-chelating heteroaryl small molecules have found widespread use as building blocks
for coordination-driven, self-assembling nanostructures. The metal-chelating noncanonical …

The choice of protein scaffolds is an important element in the design of artificial
metalloenzymes. Herein, we introduce Multidrug Resistance Regulators (MDRs) from the …

Simple strategies to produce organisms whose growth is strictly dependent on the presence
of a noncanonical amino acid are useful for the generation of live vaccines and the …

Protein-metal ion interactions play a central role in the onset of numerous diseases. When
amino acid changes lead to missense mutations in metal-binding sites, the disrupted …

Highlights•Metal-chelating non-canonical amino acids can simplify the metalloprotein
engineering and design problem.•Metal-chelating non-canonical amino acids can serve in …