Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …

Despite progress in the supportive care available for critically ill patients, few advances have
been made in the search for effective disease-modifying therapeutic options. The fact that …

Both quality improvement and clinical research efforts over the past few decades have
focused on consensus definition of sepsis and acute respiratory distress syndrome (ARDS) …

Rationale: Using microarray data, we previously identified gene expression–based
subclasses of septic shock with important phenotypic differences. The subclass-defining …

Progress has been made in the reduction of morbidity and mortality from neonatal sepsis.
However, diagnosis continues to rely primarily on conventional microbiologic techniques …

Introduction The intrinsic heterogeneity of clinical septic shock is a major challenge. For
clinical trials, individual patient management, and quality improvement efforts, it is unclear …

Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying
immunological endotypes through gene expression patterns in septic patients may lead to …