Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for
long periods, making it a probable mechanism for memory storage. LTP induction results in …

Transient information input to the brain leads to persistent changes in synaptic circuits,
contributing to the formation of memory engrams. Pre-and postsynaptic structures undergo …

Summary Poly (ADP-ribose) polymerase 1 (PARP-1) is a key eukaryotic stress sensor that
responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …

Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures
of protein kinase domains, both alone and in complexes, allows generalizations to be made …

A central question is how specificity in cellular responses to the eukaryotic second
messenger Ca2+ is achieved. Plant guard cells, that form stomatal pores for gas exchange …