Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

The visual system is beautifully crafted to transmit information of the external world to visual
processing and cognitive centers in the brain. For visual information to be relayed to the …

Our understanding of the development of the retina and visual pathways has seen
enormous advances during the past 25years. New imaging technologies, coupled with …

The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by
distinct traits that are developmentally acquired under the control of subtype-specific and …

At the optic chiasm, retinal ganglion cells (RGCs) project ipsi-or contralaterally to establish
the circuitry for binocular vision. Ipsilateral guidance programs have been characterized, but …

Strabismus is a frequent ocular disorder that develops early in life in humans. As a general
rule, it is characterized by a misalignment of the visual axes which most often appears …

Transcription factors control cell identity by regulating diverse developmental steps such as
differentiation and axon guidance. The mammalian binocular visual circuit is comprised of …

Ephrins and Eph receptors enable contact-mediated interactions between cells at every
stage of nervous system development. In spite of their broad binding affinities, Eph proteins …

Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated
during development, followed by the other retinal cell types. How are retinal progenitor cells …

Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine
cells are the first classes of neurons produced in the retina. However, an important question …