Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

Myricetin (MYR) is a flavonoid compound widely found in many natural plants including
bayberry. So far, MYR has been proven to have multiple biological functions and it is a …

Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …

Tau protein is implicated in the pathogenesis of Alzheimer's disease (AD) and other
tauopathies, but its physiological function is in debate. Mostly explored in the brain, tau is …

Alzheimer's disease (AD) is the most common age-related dementia. The alteration in
metabolic characteristics determines the prognosis. Patients at risk show reduced glucose …

Metformin as a first-line drug for type 2 diabetes mellitus (T2DM) treatment is widely studied.
Metformin can reduce liver glucose output and improve insulin resistance. Recent evidence …

Alzheimer's disease (AD) is a progressive devastating neurodegenerative disorder
characterized by extracellular amyloid beta (Aβ 42) plaque formation, hyperphosphorylation …

Around 40% of dementia risk is attributable to modifiable risk factors such as physical
inactivity, hypertension, diabetes and obesity. Recently, sleep disorders, including …

The number of people with dementia is rapidly growing along with the aging of society and
is becoming a social issue worldwide. The results of recent clinical and basic studies have …

Background Because of high prevalence of Alzheimer's disease (AD) in low-and middle-
income countries (LMICs), there is an urgent need for inexpensive and minimally invasive …