Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Pacemaker and conduction system myocytes play crucial roles in initiating and regulating
the contraction of the cardiac chambers. Genetic defects, acquired diseases, and aging …

The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging,
heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety …

All the myocytes within the heart have the capacity to conduct the cardiac impulse. A
population of myocytes is specialized so as to generate the cardiac impulse and then to …

It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …

Cardiac arrhythmias and conduction disturbances are accompanied by structural
remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction …