Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

The cytotoxic effect of anti-cancer drugs relies on their ability to induce programmed cell
death known as apoptosis. Evading apoptosis is a common characteristic of cancer cells …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Hepatocellular carcinoma (HCC) represents the third cause of cancer death in men
worldwide, and its increasing incidence can be explained by the increasing occurrence of …

Globally with over 10 million deaths per year, cancer is the most transversal disease across
countries, cultures, and ethnicities, affecting both developed and developing regions …

The aim of the current review was to provide a new, in-depth insight into possible
pharmacological targets of amantadine to pave the way to extending its therapeutic use to …

Background Acute myeloid leukemia (AML) remains a devastating disease with a 5-year
survival rate of less than 30%. AML treatment has undergone significant changes in recent …

Fluorescent molecular probes are very powerful tools that have been generally applied in
cell imaging in the research fields of biology, pathology, pharmacology, biochemistry, and …