The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

The sarcomere as the smallest contractile unit is prone to alterations in its functional,
structural and associated proteins. Sarcomeric dysfunction leads to heart failure or …

CRYAB is a member of the small heat shock protein family, first discovered in the lens of the
eye, and involved in various diseases, such as eye and heart diseases and even cancers …

Restrictive cardiomyopathy is a rare cardiac disease causing severe diastolic dysfunction,
ventricular stiffness and dilated atria. In consequence, it induces heart failure often with …

The ability of cells to respond to stress is central to health. Stress can damage folded
proteins, which are vulnerable to even minor changes in cellular conditions. To maintain …

The small heat shock proteins (sHSPs), whose molecular weight ranges from 12∼ 43 kDa,
are members of the heat shock protein (HSP) family that are widely found in all organisms …

Fast skeletal myosin-binding protein-C (fMyBP-C) is one of three MyBP-C paralogs and is
predominantly expressed in fast skeletal muscle. Mutations in the gene that encodes fMyBP …

Ethnopharmacological relevance Excessive UV irradiation and ROS exposure are the main
contributors of ocular pathologies. Pseudobulb of Dendrobium nobile Lindl. is one of the …

HSPB5 or alpha B-crystallin (CRYAB), originally identified as lens protein, is one of the most
widespread and represented of the human small heat shock proteins (sHSPs). It is greatly …