The balance between cell survival and death is under tight genetic control. A multiplicity of
extracellular signals and intracellular mediators is involved in maintaining this balance …

Embryonic metanephroi, differentiating into the adult kidney, have come to be a generally
accepted model system for organogenesis. Nephrogenesis implies a highly controlled …

Background In general, myocyte death in myocardial infarctions (MIs) is attributed to
necrosis, but recently the involvement of apoptosis has been suggested. The ratio of bcl-2 …

Apoptosis plays a central role not only in the physiological processes of kidney growth and
remodeling, but also in various human renal diseases and drug-induced nephrotoxicity. We …

BACKGROUND The bcl‐2 oncoprotein confers a survival advantage to cells by inhibiting
programmed cell death (PCD) or apoptosis. Overexpression of bcl‐2 probably plays a role in …

The promotion of cell survival and regeneration in acute renal failure (ARF) is important for
restitution of renal function. This study analyzes the temporal and spatial relationship …

PURPOSE: We characterize the genetic abnormalities associated with pathological
subtypes of renal tumors, which may help diagnosis or prognostication. MATERIALS AND …

abstract The Wilms' tumor 1 (wt1) gene is one of at least three genes that are involved in the
development of Wilms' tumor, a pediatric kidney cancer. The expression pattern of the gene …

There are at present disparate published results with regard to the relevance of the Bcl-2
gene family, levels of apoptosis, and cell proliferation in the development and progression of …

The clinical course of prostate cancer is highly variable and cannot satisfactorily be
predicted by histological criteria alone. To study the prognostic significance of Bcl-2 and p53 …