Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

Breast cancer rises as the most commonly diagnosed cancer in 2020. Among women,
breast cancer ranks first in both cancer incidence rate and mortality. Treatment resistance …

Cancer stem cells (CSCs) as a small subpopulation in tumor bulk are believed to initiate
tumor formation and are responsible for the resistance to cancer therapy. The proliferation …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Background Understanding the intricate signaling network involved in triple-negative breast
cancer (TNBC) represents a challenge for developing novel therapeutic approaches. Here …

The molecular repertoire promoting cancer cell plasticity is not fully elucidated. Here, we
propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate …

Introduction: For decades, the role of glycans and glycoproteins in the progression of breast
cancer and other cancers have been evaluated. Through extensive studies focused on …

Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous
system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of …