Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

In this review we describe an emerging understanding of the roles of the Extracellular-signal
regulated kinase/mitogen-activated protein kinase (ERK/MAPK) cascade in learning and …

The effects of lead (Pb2+) on human health have been recognized since antiquity. However,
it was not until the 1970s that seminal epidemiological studies provided evidence on the …

N-methyl-D-aspartate receptors (NMDAR) overactivation is linked to neurodegeneration.
The current prevailing theory suggests that synaptic and extrasynaptic NMDAR (syn-and ex …

Although the PI3K (phosphatidylinositol 3-kinase) pathway typically regulates cell growth
and survival, increasing evidence indicates the involvement of this pathway in neural …

N‐Methyl‐D‐aspartate receptors (NMDARs) have two opposing roles in the brain. On the
one hand, NMDARs control critical events in the formation and development of synaptic …

The extracellular signal‐regulated kinases (ERK) signalling cascade is a key pathway that
mediates the NMDA receptor (NMDAR)‐dependent neuronal plasticity and survival …

The expression of IL-1 is elevated in the CNS in diverse neurodegenerative disorders,
including Alzheimer's disease. The hypothesis was tested that IL-1β renders neurons …

How signals from the surface of neurons get relayed to the nucleus and other points within
the cells (signal transduction) is a dimension of neurotransmission in schizophrenia that is …