Context: Type 1 diabetes is a heterogeneous disorder characterized by severe β-cell loss.
The great majority of patients have type 1A or immune-mediated diabetes. Synthesis: There …

The early developments of brain positron emission tomography (PET), including the
methodological advances that have driven progress, are outlined. The considerable past …

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …

Abstract Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction
of insulin-producing pancreatic β cells. Immune modulators have achieved some success in …

The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …

The hallmark of type 1 diabetes is autoimmune destruction of the insulin-producing β-cells of
the pancreatic islets. Autoimmune diabetes has been difficult to study or treat because it is …

Radiotracer imaging is characterised by high in vivo sensitivity, with a detection limit in the
lower picomolar range. Therefore, radiotracers represent a valuable tool for imaging …

Recent studies on gene expression of β-cell mass (BCM) in the pancreas showed that
vesicular monoamine transporter 2 (VMAT2) is highly expressed in the BCM (mainly in the …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

Abstract Vesicular monoamine transporter 2 (VMAT2) is expressed in pancreatic beta cells
and has recently been proposed as a target for measurement of beta cell mass in vivo. We …