Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Abstract Sirtuins (SIRT1-SIRT7), a family of nicotinamide adenine dinucleotide (NAD+)-
dependent enzymes, are key regulators of life span and metabolism. In addition to acting as …

Simple Summary There are diverse reports of the dual role of sirtuin genes and proteins in
breast and prostate cancers. This review discusses the current information on the tumor …

The sirtuin (SIRT) protein family has been of major research interest over the last decades
because of their involvement in aging, cancer, and cell death. SIRTs have been implicated …

In this work, the protective effect of apple polyphenol extract (APE) on hepatic steatosis was
investigated. Thirty-two C57BL/6J mice were assigned randomly to control group, hepatic …

Prostate cancer (PCa) remains a critical global health challenge, with high mortality rates
and significant heterogeneity, particularly in advanced stages. While early-stage PCa is …

We create and share a new red fluorophore, along with a set of strains, reagents and
protocols, to make it faster and easier to label endogenous Caenorhabditis elegans proteins …

The stress-inducible and senescence-associated tumor suppressor SIRT4, a member of the
family of mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5), regulates bioenergetics and …

Axin1 is a fundamental scaffolding protein of the destruction complex in the canonical Wnt
signaling pathway, which plays a critical role in various biological processes. However, how …

Sirtuins (SIRTs) are members of the silent information regulator-2 family. They are a
conserved family of nicotinamide adenine dinucleotide-dependent protein lysine …