Device profile of the percept PC deep brain stimulation system for the treatment of Parkinson's disease and related disorders

J Jimenez-Shahed - Expert Review of Medical Devices, 2021 - Taylor & Francis
Introduction: Several software and hardware advances in the field of deep brain stimulation
(DBS) have been realized in recent years and devices from three manufacturers are …

Implantable devices: issues and challenges

K Bazaka, MV Jacob - Electronics, 2012 - mdpi.com
Ageing population and a multitude of neurological and cardiovascular illnesses that cannot
be mitigated by medication alone have resulted in a significant growth in the number of …

Closed-loop deep brain stimulation is superior in ameliorating parkinsonism

B Rosin, M Slovik, R Mitelman, M Rivlin-Etzion… - Neuron, 2011 - cell.com
Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for
advanced Parkinson's disease (PD) management. However, the mechanisms underlying …

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

A Eusebio, W Thevathasan, LD Gaynor… - Journal of Neurology …, 2011 - jnnp.bmj.com
Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a
highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of …

[HTML][HTML] Closed-loop neurostimulation: the clinical experience

FT Sun, MJ Morrell - Neurotherapeutics, 2014 - Elsevier
Neurostimulation is now an established therapy for the treatment of movement disorders,
pain, and epilepsy. While most neurostimulation systems available today provide stimulation …

Design and validation of a fully implantable, chronic, closed-loop neuromodulation device with concurrent sensing and stimulation

S Stanslaski, P Afshar, P Cong, J Giftakis… - … on Neural Systems …, 2012 - ieeexplore.ieee.org
Chronically implantable, closed-loop neuromodulation devices with concurrent sensing and
stimulation hold promise for better understanding the nervous system and improving …

What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?

S Little, P Brown - Annals of the New York Academy of …, 2012 - Wiley Online Library
Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential
to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing …

Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

NC Swann, C De Hemptinne, S Miocinovic… - Journal of …, 2017 - thejns.org
OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. The
development of neuromodulation therapies depends on a better understanding of these …

Landscape and future directions of machine learning applications in closed-loop brain stimulation

AS Chandrabhatla, IJ Pomeraniec, TM Horgan… - NPJ Digital …, 2023 - nature.com
Brain stimulation (BStim) encompasses multiple modalities (eg, deep brain stimulation,
responsive neurostimulation) that utilize electrodes implanted in deep brain structures to …

Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness

MC Lo, AS Widge - International review of psychiatry, 2017 - Taylor & Francis
Despite deep brain stimulation's positive early results in psychiatric disorders, well-designed
clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit …