The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

The microbiome plays a key role in health and disease, and there has been considerable
interest in therapeutic targeting of the microbiome as well as mining this rich resource in …

For those using drugs to treat infants and children, the integration of developmental
pharmacology is crucial to appropriate clinical practice. Changes in metabolic capacity …

The bioactivities, dietary sources, bioavailability, metabolism, and epidemiology of 3
flavonoids, quercetin, hesperetin, and naringenin, are reviewed. The use of their plasma …

Written at a level comprehensible to non-experts, this handbook covers the current state of
encapsulation and controlled released technologies, presenting the fundamental processes …

Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute,
sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often …

Recent advances in computational methods applied to the fields of drug delivery and
biopharmaceutics will be reviewed with a focus on prediction of the impact of physiological …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Drugs may be administered via different routes, the oral route generally being the preferred
for reasons of ease and compliance by the patient. Absorption via these routes will take …

Background The calcineurin inhibitors cyclosporine (INN, ciclosporin) and tacrolimus have a
narrow therapeutic index and show considerable interindividual variability in their …