Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
Repurposing drug molecules for new pulmonary therapeutic interventions
PP Mehta, VS Dhapte-Pawar - Drug Delivery and Translational Research, 2021 - Springer
Drug repurposing with novel strategies has substantially contributed to the identification and
analysis of new molecules for better pulmonary intervention. This review would offer insights …
analysis of new molecules for better pulmonary intervention. This review would offer insights …
Therapeutic targeting of repurposed anticancer drugs in Alzheimer's disease: Using the multiomics approach
D Advani, P Kumar - ACS omega, 2021 - ACS Publications
Aim/Hypothesis: The complexity and heterogeneity of multiple pathological features make
Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an …
Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an …
Mucosal inflammatory and wound healing gene programmes reveal targets for stricturing behaviour in paediatric Crohn's disease
Y Haberman, P Minar, R Karns… - Journal of Crohn's …, 2021 - academic.oup.com
Abstract Background and Aims Ileal strictures are the major indication for resective surgery
in Crohn's disease [CD]. We aimed to define ileal gene programmes present at diagnosis …
in Crohn's disease [CD]. We aimed to define ileal gene programmes present at diagnosis …
Eicosatetraynoic acid and butyrate regulate human intestinal organoid mitochondrial and extracellular matrix pathways implicated in Crohn's disease strictures
I Jurickova, E Bonkowski, E Angerman… - Inflammatory Bowel …, 2022 - academic.oup.com
Abstract Background Perturbagen analysis of Crohn's disease (CD) ileal gene expression
data identified small molecules including eicosatetraynoic acid (ETYA), which may exert an …
data identified small molecules including eicosatetraynoic acid (ETYA), which may exert an …
Niclosamide alleviates pulmonary fibrosis in vitro and in vivo by attenuation of epithelial-to-mesenchymal transition, matrix proteins & Wnt/β-catenin signaling: A drug …
Drug repurposing off late has been emerging as an inspiring alternative approach to
conventional, exhaustive and arduous process of drug discovery. It is a process of …
conventional, exhaustive and arduous process of drug discovery. It is a process of …
[HTML][HTML] The anatomy of the SARS-CoV-2 biomedical literature: Introducing the CovidX network algorithm for drug repurposing recommendation
LE Gates, AA Hamed - Journal of medical Internet research, 2020 - jmir.org
Background Driven by the COVID-19 pandemic and the dire need to discover an antiviral
drug, we explored the landscape of the SARS-CoV-2 biomedical publications to identify …
drug, we explored the landscape of the SARS-CoV-2 biomedical publications to identify …
Drug repurposing prediction and validation from clinical big data for the effective treatment of interstitial lung disease
S Siswanto, H Yamamoto, H Furuta… - Frontiers in …, 2021 - frontiersin.org
Interstitial lung diseases (ILDs) are a group of respiratory disorders characterized by chronic
inflammation and fibrosis of the pulmonary interstitial tissues. Although the etiology of ILD …
inflammation and fibrosis of the pulmonary interstitial tissues. Although the etiology of ILD …
A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease
JA Timmons, A Anighoro, RJ Brogan, J Stahl… - Elife, 2022 - elifesciences.org
Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral
infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; …
infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; …
Suppression of miR-30a-3p attenuates hepatic steatosis in non-alcoholic fatty liver disease
DR Wang, B Wang, M Yang, Z Liu, J Sun, Y Wang… - Biochemical …, 2020 - Springer
Non-alcoholic fatty liver disease (NAFLD) have a high prevalence in humans in the past two
decades. Here, we elucidated the functions of miR-30a-3p in the development of NAFLD …
decades. Here, we elucidated the functions of miR-30a-3p in the development of NAFLD …