Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from
but are likely independent of chromosomes. Due to technological advancements, eccDNAs …

Throughout the years, most plant genomic studies were focused on nuclear chromosomes.
Extrachromosomal circular DNA (eccDNA) has largely been neglected for decades since its …

T loops and telomeric G-quadruplex (G4) DNA structures pose a potential threat to genome
stability and must be dismantled to permit efficient telomere replication. Here we implicate …

Alternative lengthening of telomeres (ALT) is likely to be an important target for anticancer
treatment as∼ 10% of cancers depend on this telomere maintenance mechanism for …

The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of
mammalian chromosome-end maintenance has been unclear. We have now discovered …

Telomeres are found at the end of chromosomes and are important for chromosome stability.
Here we describe a specific telomere-associated protein: TZAP (telomeric zinc finger …

Rationale: Up to 20% of cases of idiopathic interstitial pneumonia cluster in families,
comprising the syndrome of familial interstitial pneumonia (FIP); however, the genetic basis …

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of
the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the …

Alternative Lengthening of Telomeres (ALT) activity can be deduced from the presence of
telomere length maintenance in the absence of telomerase activity. More convenient assays …

Dyskeratosis congenita (DC) and its phenotypically severe variant, Hoyeraal-Hreidarsson
syndrome (HHS), are multisystem bone-marrow-failure syndromes in which the principal …