Hair cell transduction, tuning, and synaptic transmission in the mammalian cochlea
R Fettiplace - Comprehensive Physiology, 2011 - Wiley Online Library
Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …
Cochlear health and cochlear-implant function
KC Schvartz-Leyzac, DJ Colesa, DL Swiderski… - Journal of the …, 2023 - Springer
The cochlear implant (CI) is widely considered to be one of the most innovative and
successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are …
successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are …
Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo
Mammalian hearing depends on an amplification process involving prestin, a voltage-
sensitive motor protein that enables cochlear outer hair cells (OHCs) to change length and …
sensitive motor protein that enables cochlear outer hair cells (OHCs) to change length and …
Vibration hotspots reveal longitudinal funneling of sound-evoked motion in the mammalian cochlea
NP Cooper, A Vavakou, M van der Heijden - Nature communications, 2018 - nature.com
The micromechanical mechanisms that underpin tuning and dynamic range compression in
the mammalian inner ear are fundamental to hearing, but poorly understood. Here, we …
the mammalian inner ear are fundamental to hearing, but poorly understood. Here, we …
In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective
Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …
Two-dimensional cochlear micromechanics measured in vivo demonstrate radial tuning within the mouse organ of Corti
The exquisite sensitivity and frequency discrimination of mammalian hearing underlie the
ability to understand complex speech in noise. This requires force generation by cochlear …
ability to understand complex speech in noise. This requires force generation by cochlear …
Reticular lamina and basilar membrane vibrations in living mouse cochleae
T Ren, W He, D Kemp - Proceedings of the National …, 2016 - National Acad Sciences
It is commonly believed that the exceptional sensitivity of mammalian hearing depends on
outer hair cells which generate forces for amplifying sound-induced basilar membrane …
outer hair cells which generate forces for amplifying sound-induced basilar membrane …
Amplification and suppression of traveling waves along the mouse organ of Corti: evidence for spatial variation in the longitudinal coupling of outer hair cell-generated …
Mammalian hearing sensitivity and frequency selectivity depend on a mechanical
amplification process mediated by outer hair cells (OHCs). OHCs are situated within the …
amplification process mediated by outer hair cells (OHCs). OHCs are situated within the …
Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae
W He, D Kemp, T Ren - Elife, 2018 - elifesciences.org
Auditory sensory outer hair cells are thought to amplify sound-induced basilar membrane
vibration through a feedback mechanism to enhance hearing sensitivity. For optimal …
vibration through a feedback mechanism to enhance hearing sensitivity. For optimal …
Cochlear motion across the reticular lamina implies that it is not a stiff plate
Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL)
through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow …
through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow …