Subarachnoid hemorrhage (SAH) can lead to devastating neurological outcomes, and there
are few pharmacologic treatments available for treating this condition. Both animal and …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Nonsteroidal anti-inflammatory drugs are among the most commonly administered drugs in
the perioperative period due to their prominent role in pain management. However, they …

Highlights•Smooth muscle dysfunction underlies many disorders.•KCNQ-genes are
expressed in smooth muscle as well as in brain and heart.•Enhancing KV 7 channels …

Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across
the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs) …

Objective—Middle cerebral artery (MCA) diameter is regulated by inherent myogenic activity
and the effect of potent vasodilators such as calcitonin gene-related peptide (CGRP) …

Cone snails produce a distinctive repertoire of venom peptides that are used both as a
defense mechanism and also to facilitate the immobilization and digestion of prey. These …

Smooth muscle cells provide crucial contractile functions in visceral, vascular, and lung
tissues. The contractile state of smooth muscle is largely determined by their electrical …

Flupirtine was developed long before KV 7 (KCNQ) channels were known. However, it was
clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti …

Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …