In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor
microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell …

Objectives: Intervertebral disc degeneration (IDD) is widely accepted as a cause of low back
pain and related degenerative musculoskeletal disorders. Nucleus pulposus (NP) cell …

The reactive oxygen species (ROS) are tightly associated with endoplasmic reticulum (ER)
stress. Thus, the deep and visual insight of aberrant ROS fluctuations in the ER can help us …

Dicarbonyl stress occurs when dicarbonyl metabolites (ie, methylglyoxal, glyoxal and 3-
deoxyglucosone) accumulate as a consequence of their increased production and/or …

Photodynamic therapy (PDT) is a robust cancer treatment modality, and the precise
spatiotemporal control of its subcellular action site is crucial for its effectiveness. However …

Over the last few years, significant attention has been paid to develop metal complexes for
different cellular organelle specific imaging agents and to achieve organelle targeting …

The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular
matrix (ECM) is an important TME component. Collagen is a major ECM component that …

The review highlights the mechanisms through which methylglyoxal is formed in diabetes,
and how methylglyoxal contributes to the mechanisms that drive CKD in diabetes …

Diabetic wound healing (DWH) represents a major complication of diabetes where
inflammation is a key impediment to proper healing. The cyclic GMP-AMP synthase (cGAS) …