While considerable progress has been made in studying genetic and cellular aspects of
metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of …

PurposePatients with advanced cancer can experience debilitating physical symptoms,
making participation in exercise programs difficult. This systematic review investigated the …

In patients with breast cancer, lower bone mineral density increases the risk of bone
metastasis. Although the relationship between bone-matrix mineralization and tumour-cell …

The current knowledge of bone marrow mechanics is limited to its viscous properties,
neglecting the elastic contribution of the extracellular matrix. To get a more complete view of …

Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of
the most common sites of metastasis for many solid tumors. Once cancer cells colonize in …

Metastatic disease is a frequent complication of advanced cancer, with bone representing
one of the most common sites of metastatic occurrence. Patients with bone metastases …

Bone metastasis is a common, yet serious, complication of breast cancer. Breast cancer
cells that extravasate from blood vessels to the bone devastate bone quality by interacting …

Breast cancer frequently metastasizes to bone, causing osteolytic lesions. However, how
factors secreted by primary tumors affect the bone microenvironment before the osteolytic …

Although the skeleton is one of the predominant sites for breast cancer metastasis, why
breast cancer cells often become dormant after homing to bone is not well understood. Here …

Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor
cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte …