Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators

Z Wu, D Lin, Y Li - Nature Reviews Neuroscience, 2022 - nature.com
Neurotransmitters and neuromodulators have a wide range of key roles throughout the
nervous system. However, their dynamics in both health and disease have been challenging …

Fluorescent proteins and genetically encoded biosensors

M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Wearable materials with embedded synthetic biology sensors for biomolecule detection

PQ Nguyen, LR Soenksen, NM Donghia… - Nature …, 2021 - nature.com
Integrating synthetic biology into wearables could expand opportunities for noninvasive
monitoring of physiological status, disease states and exposure to pathogens or toxins …

Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo

Y Zhuo, B Luo, X Yi, H Dong, X Miao, J Wan… - Nature …, 2024 - nature.com
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

KK Chan, D Dorosky, P Sharma, SA Abbasi, JM Dye… - Science, 2020 - science.org
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble …

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

F Sun, J Zhou, B Dai, T Qian, J Zeng, X Li, Y Zhuo… - Nature …, 2020 - nature.com
Dopamine (DA) plays a critical role in the brain, and the ability to directly measure
dopaminergic activity is essential for understanding its physiological functions. We therefore …

Cell-free biosensors for rapid detection of water contaminants

JK Jung, KK Alam, MS Verosloff, DA Capdevila… - Nature …, 2020 - nature.com
Lack of access to safe drinking water is a global problem, and methods to reliably and easily
detect contaminants could be transformative. We report the development of a cell-free in …

Cell-free gene expression: an expanded repertoire of applications

AD Silverman, AS Karim, MC Jewett - Nature Reviews Genetics, 2020 - nature.com
Cell-free biology is the activation of biological processes without the use of intact living cells.
It has been used for more than 50 years across the life sciences as a foundational research …

The structural basis of odorant recognition in insect olfactory receptors

J Del Mármol, MA Yedlin, V Ruta - Nature, 2021 - nature.com
Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …

Cell-free gene expression

D Garenne, MC Haines, EF Romantseva… - Nature reviews …, 2021 - nature.com
Cell-free gene expression (CFE) emerged as an alternative approach to living cells for
specific applications in protein synthesis and labelling for structural biology and proteomics …