THROMBOCYTOPENIA, anemia, lymphocytopenia, mono-cytopenia, and neutropenia and
permutations of these abnormalities are found in most patients with acquired …

Hematologic abnormalities are among the most common manifestations of advanced human
immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) …

Deletions and/or mutations of p53 are relatively rare and late events in the natural history of
B-cell chronic lymphocytic leukemia (B-CLL). However, it is unknown whether p53 signaling …

Hematologic and immunologic functions were examined in 19 HIV-negative infants of HIV-
positive mothers and 19 control infants of HIV-negative mothers. Control infants were …

Purpose: To elucidate new molecular mechanisms able to downregulate the mRNA levels of
key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective. Experimental …

Infection by human immunodeficiency virus type 1 (HIV-1) leads to progressive destruction
of the CD4+ T-cell subset, resulting in immune deficiency and AIDS. The specific binding of …

Infection of primates by HIV-1 and SIV induces multiple hematological abnormalities of
central hematopoietic origin. Although these defects greatly contribute to the …

It has been recently reported that murine hematopoietic stem cells and progenitors express
low levels of CD4. In this study, we have investigated by phenotypic and functional analysis …

We investigated the expression of CD4 antigen in normal bone marrow (BM) samples,
enriched in CD34+ hematopoietic progenitor cells. At flow cytometry, a significant fraction …

The goal of antiretroviral treatment (ART) in HIV-1 patients is immune reconstitution
following control of viral replication. CD4+ cell number/proportions are a crude but essential …