The serotonin system in autism spectrum disorder: From biomarker to animal models

CL Muller, AMJ Anacker, J Veenstra-VanderWeele - Neuroscience, 2016 - Elsevier
Elevated whole blood serotonin, or hyperserotonemia, was the first biomarker identified in
autism spectrum disorder (ASD) and is present in more than 25% of affected children. The …

Identification and evaluation of children with autism spectrum disorders

CP Johnson, SM Myers - Pediatrics, 2007 - publications.aap.org
Autism spectrum disorders are not rare; many primary care pediatricians care for several
children with autism spectrum disorders. Pediatricians play an important role in early …

Genome-wide association study identifies 48 common genetic variants associated with handedness

G Cuellar-Partida, JY Tung, N Eriksson… - Nature human …, 2021 - nature.com
Handedness has been extensively studied because of its relationship with language and the
over-representation of left-handers in some neurodevelopmental disorders. Using data from …

Advances in autism genetics: on the threshold of a new neurobiology

BS Abrahams, DH Geschwind - Nature reviews genetics, 2008 - nature.com
Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …

Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder

G Dawson - Development and psychopathology, 2008 - cambridge.org
Advances in the fields of cognitive and affective developmental neuroscience,
developmental psychopathology, neurobiology, genetics, and applied behavior analysis …

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

E Santini, TN Huynh, AF MacAskill, AG Carter, P Pierre… - Nature, 2013 - nature.com
Autism spectrum disorders (ASDs) are an early onset, heterogeneous group of heritable
neuropsychiatric disorders with symptoms that include deficits in social interaction skills …

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

MG Butler, MJ Dasouki, XP Zhou… - Journal of medical …, 2005 - jmg.bmj.com
The genetic aetiology of autism remains elusive. Occasionally, individuals with Cowden
syndrome (a cancer syndrome) and other related hamartoma disorders such as Bannayan …

Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene

M Alarcón, BS Abrahams, JL Stone, JA Duvall… - The American Journal of …, 2008 - cell.com
Autism is a genetically complex neurodevelopmental syndrome in which language deficits
are a core feature. We describe results from two complimentary approaches used to identify …

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

NNJ Rommelse, B Franke, HM Geurts… - European child & …, 2010 - Springer
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both
highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur …

The genetics of autistic disorders and its clinical relevance: a review of the literature

CM Freitag - Molecular psychiatry, 2007 - nature.com
Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …