Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …

The transforming growth factor β (TGF-β) family controls many fundamental aspects of
cellular behavior. With advances in the molecular details of the TGF-β signaling cascade …

With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …

Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the
regulation of gene expression. They are involved in the fine-tuning of fundamental biological …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …

MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating
oncogenic and tumor suppressor pathways they could, in principle, contribute to …

The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …