HIV/AIDS and lipodystrophy: implications for clinical management in resource‐limited settings

JL Finkelstein, P Gala, R Rochford… - African Journal of …, 2015 - journals.lww.com
Introduction: Lipodystrophy is a term used to describe a metabolic complication of fat loss, fat
gain, or a combination of fat loss and gain, which is associated with some antiretroviral …

A meta-analysis of the metabolic syndrome prevalence in the global HIV-infected population

KA Nguyen, N Peer, EJ Mills, AP Kengne - PloS one, 2016 - journals.plos.org
Background Cardio-metabolic risk factors are of increasing concern in HIV-infected
individuals, particularly with the advent of antiretroviral therapy (ART) and the subsequent …

Frailty in HIV-infected adults in South Africa

S Pathai, C Gilbert, HA Weiss, C Cook… - JAIDS Journal of …, 2013 - journals.lww.com
Objectives: Some evidence suggests that HIV infection is associated with premature frailty—
a syndrome typically viewed as being related to ageing. We determined the prevalence and …

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain

SB Smith, I Reenilä, PT Männistö, GD Slade… - Pain, 2014 - journals.lww.com
Genetic interactions between catechol-O-methyltransferase val 158 met with estrogen
receptor 1 and guanosine-5-triphosphate cyclohydrolase 1 polymorphisms modulate …

Pharmacogenetic considerations in the treatment of HIV

VS Mattevi, CFS Tagliari - Pharmacogenomics, 2017 - Taylor & Francis
After the introduction of highly active antiretroviral therapy in the 1990s, the perception of the
diagnosis of HIV infection gradually shifted from a 'death sentence'to a chronic disease …

[HTML][HTML] Estrogen receptor gene polymorphisms and lung adenocarcinoma risk in never-smoking women

KY Chen, CF Hsiao, GC Chang, YH Tsai, WC Su… - Journal of Thoracic …, 2015 - Elsevier
Introduction: The association between estrogen receptor (ER) gene polymorphism and lung
cancer risk is rarely studied. This study aimed to explore the ER gene polymorphisms …

[HTML][HTML] Prevalence and factors associated with lipodystrophy in AIDS patients

LB Della Justina, MC Luiz, R Maurici… - Revista da Sociedade …, 2014 - SciELO Brasil
Introduction: The published literature shows an increased occurrence of adverse events,
such as human immunodeficiency virus (HIV)-associated lipodystrophy syndrome, that are …

Viral mechanisms of adipose dysfunction: lessons from HIV-1 Vpr

N Agarwal, A Balasubramanyam - Adipocyte, 2015 - Taylor & Francis
HIV-associated lipodystrophy is a heterogeneous, evolving condition associated with
fundamental defects in adipose tissue differentiation, turnover and function. Although many …

Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome

CFS Tagliari, CN de Oliveira, GM Vogel… - … and Molecular Biology, 2020 - SciELO Brasil
HIV-infected individuals on chronic use of highly active antiretroviral therapy (HAART) are
more likely to develop adipose tissue and metabolic disorders, such as lipodystrophy (LD) …

Polymorphisms in adiponectin receptor genes are associated with lipodystrophy‐related phenotypes in HIV‐infected patients receiving antiretroviral therapy

JK Castilhos, E Sprinz, RK Lazzaretti… - HIV …, 2015 - Wiley Online Library
Objectives Adiponectin is a circulating peptide secreted by mature adipocytes that may act
as a regulator of glucose and lipid metabolism. This study aimed to investigate the …