Circuit mechanisms of Parkinson's disease
MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
Corticostriatal connectivity and its role in disease
GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …
involved in motivated behaviour. These axonal projections are formed by two distinct …
Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease
C De Hemptinne… - Proceedings of the …, 2013 - National Acad Sciences
An important mechanism for large-scale interactions between cortical areas involves
coupling between the phase and the amplitude of different brain rhythms. Could basal …
coupling between the phase and the amplitude of different brain rhythms. Could basal …
Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex
Much recent discussion about the origin of Parkinsonian symptoms has centered around the
idea that they arise with the increase of beta frequency waves in the EEG. This activity may …
idea that they arise with the increase of beta frequency waves in the EEG. This activity may …
Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state
A Galvan, A Devergnas, T Wichmann - Frontiers in neuroanatomy, 2015 - frontiersin.org
In patients with Parkinson's disease and in animal models of this disorder, neurons in the
basal ganglia and related regions in thalamus and cortex show changes that can be …
basal ganglia and related regions in thalamus and cortex show changes that can be …
Motor thalamus integration of cortical, cerebellar and basal ganglia information: implications for normal and parkinsonian conditions
C Bosch-Bouju, BI Hyland… - Frontiers in computational …, 2013 - frontiersin.org
Motor thalamus (Mthal) is implicated in the control of movement because it is strategically
located between motor areas of the cerebral cortex and motor-related subcortical structures …
located between motor areas of the cerebral cortex and motor-related subcortical structures …
Specialized subpopulations of deep-layer pyramidal neurons in the neocortex: bridging cellular properties to functional consequences
Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …
[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
[HTML][HTML] Clinical neurophysiology of Parkinson's disease and parkinsonism
R Chen, A Berardelli, A Bhattacharya… - Clinical neurophysiology …, 2022 - Elsevier
This review is part of the series on the clinical neurophysiology of movement disorders. It
focuses on Parkinson's disease and parkinsonism. The topics covered include the …
focuses on Parkinson's disease and parkinsonism. The topics covered include the …