Drugs are introduced into the body by numerous routes such as enteral (oral, sublingual and
rectum administration), parenteral (intravascular, intramuscular, subcutaneous and …

For the first time, an overview of dendrimers in combination with natural products and
analogues as anti-cancer agents is presented. This reflects the development of drug delivery …

In order to enhance intracellular uptake and accumulation of therapeutic nucleic acids for
improved gene therapy methods, numerous delivery vectors have been elaborated. Based …

The main objective of nanomedicine research is the development of nanoparticles as drug
delivery systems or drugs per se to tackle diseases as cancer, which are a leading cause of …

The synthesis of a new generation of highly cytotoxic tubulysin analogues (ie, tubugis) is
described. In the key step, the rare, unstable, and synthetically difficult to introduce tertiary …

Cancer is currently one of the major diseases that has gained a lot of scientific attention.
Conventional cancer therapeutics involve surgical removal of tumors from patients followed …

A streamlined total synthesis of N 14-desacetoxytubulysin H (Tb1) based on a C–H
activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described …

Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-
fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work …

Isocyanide multicomponent reactions assemble more than two reaction components by
exploiting the reactivity of the isocyanide carbon atom toward addition of electrophiles and …

Covering: 2000 to 2014 Since their first report in 2000, tubulysins have sparked great
interest for development as anti-cancer agents due to their exceptionally potent …