Cancer cells take advantage of signaling cascades to meet their requirements for sustained
growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation …

Triple negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer
(BC) for which limited therapeutic options are available. Recently, β-blockers (BBs) have …

Background: Lower survival rates for many cancer types correlate with changes in nuclear
size/scaling in a tumor-type/tissue-specific manner. Hypothesizing that such changes might …

Acute myeloid leukemia (AML) is an aggressive and heterogeneous hematologic
malignancy. In elderly patients, AML incidence is high and has a poor prognosis due to a …

Abstract β-Arrestins (βArrs) are intracellular signal regulating proteins. Their expression
level varies in some cancers and they have a significant impact on cancer cell function. In …

Cetuximab is a monoclonal antibody developed to inhibit the binding of growth factors and
the subsequent activation of epidermal growth factor receptor (EGFR). Triple‑negative breast …

The advancement of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics
has made it possible to infer interactions amongst heterogeneous cells and their …

It was previously shown that the estrogen-receptor negative breast cancer cell line MBA-MD-
231 expresses high levels of A2B adenosine receptors as the sole adenosine receptor …

Research on metastasis has recently regained considerable interest with the hope that
single cell technologies might reveal the most critical changes that support tumor spread …

Background: Triple-negative breast cancer (TNBC) is considered to be the most malignant
subtype of breast cancer (BC). Heparanase (HPSE) has been reported to contribute to tumor …