Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …

Important insights into the selection pressures and core molecular modules contributing to
the evolution of pain-related processes have come from studies of nociceptive systems in …

Sensitization is a form of non-associative conditioning in which amplification of behavioral
responses can occur following presentation of an aversive or noxious stimulus …

Numerous studies have implicated the cAMP-protein kinase A (PKA) pathway in producing
hyperexcitability of dorsal root ganglia (DRG) sensory neurons under conditions associated …

Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but
rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain …

Noxious stimulation can trigger persistent sensitization of somatosensory systems that
involves memory–like mechanisms. Here we report that noxious stimulation of the mollusc …

Learning can lead to changes in the intrinsic excitability of neurons. However, the extent to
which these changes persist and the role they have in the expression of memory remain …

Injury or inflammation affecting sensory neurons in dorsal root ganglia (DRG) causes
hyperexcitability of DRG neurons that can lead to spontaneous firing and neuropathic pain …

Little is known about intracellular signaling mechanisms that persistently excite neurons in
pain pathways. Persistent spontaneous activity (SA) generated in the cell bodies of primary …

Background and purpose: Protein kinase (PK) A and the ε isoform of PKC (PKCε) are
involved in the development of hypernociception (increased sensitivity to noxious or …