Heterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a
severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal …

The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been
associated with increased risk of attention deficit hyperactivity disorder (ADHD) and …

Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G
protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate …

Adhesion G protein-coupled receptors (aGPCRs) form a sub-group within the GPCR
superfamily. Their distinctive structure contains an abnormally large N-terminal, extracellular …

The adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but
its impact on male reproduction and fertility has not been examined. Using a mouse model …

A large portion of the human GPCRome is still in the dark and understudied, consisting even
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …

Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal
guidance factors, that is implicated in planar polarity and control of cell movements. By …

Polycystin-1, whose mutation is the most frequent cause of autosomal dominant polycystic
kidney disease, is an extremely large and multi-faceted membrane protein whose primary or …

The chemotactic G protein–coupled receptor GPR183 and its most potent endogenous
oxysterol ligand 7α, 25-dihydroxycholesterol (7α, 25-OHC) are important for immune cell …

GPR56, an adhesion G-protein coupled receptor (aGPCRs) with constitutive and ligand-
promoted activity, is involved in many physiological and pathological processes. Whether …