Streptozotocin-induced type 1 and 2 diabetes in rodents: A model for studying diabetic cardiac autonomic neuropathy

OM Akinlade, BV Owoyele, AO Soladoye - African health sciences, 2021 - ajol.info
Background: Several animal models are continually being developed to study diabetic
complication. Several conflicting regimen for diabetes induction exist in the literature with …

Combined curcumin and luteolin synergistically inhibit colon cancer associated with notch1 and TGF-β signaling pathways in cultured cells and xenograft mice

R Aromokeye, H Si - Cancers, 2022 - mdpi.com
Simple Summary One of the significant issues of the anti-cancer effects of phytochemicals,
bioactive compounds from foods, and other plants, is that the effective dosages of the …

Conventional histological and cytological staining with simultaneous immunohistochemistry enabled by invisible chromogens

LE Morrison, MR Lefever, HN Lewis… - Laboratory …, 2022 - nature.com
Conventional histological stains, such as hematoxylin plus eosin (H&E), and
immunohistochemistry (IHC) are mainstays of histology that provide complementary …

Kaempferol prevents cadmium chloride-induced liver damage by upregulating Nrf2 and suppressing NF-κB and keap1

AS Alshehri, AF El-Kott, MSA El-Gerbed… - … Science and Pollution …, 2022 - Springer
This study evaluated the protective effect of kaempferol, a natural flavonoid, against
cadmium chloride (CdCl 2)-induced liver damage and examined the possible anti …

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism

E Mendoza-Torres, JA Riquelme, A Vielma… - Pharmacological …, 2018 - Elsevier
Abstract Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been
shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that …

Identification of intraductal carcinoma of the prostate on tissue specimens using Raman micro-spectroscopy: a diagnostic accuracy case–control study with multicohort …

AA Grosset, F Dallaire, T Nguyen, M Birlea… - PLoS …, 2020 - journals.plos.org
Background Prostate cancer (PC) is the most frequently diagnosed cancer in North
American men. Pathologists are in critical need of accurate biomarkers to characterize PC …

Evaluation of Anti-Nociceptive, Anti-Inflammatory, and Anti-Fibrotic effects of noscapine against a rat model of Achilles tendinopathy

Z Najafi, Z Moosavi, VB Rahimi, G Hashemitabar… - International …, 2024 - Elsevier
During tendinopathy, prolonged inflammation results in fibrosis and the adherence of
tendons to the adjacent tissues, causing discomfort and movement disorders. As a natural …

[HTML][HTML] Mitigation of cisplatin-induced cardiotoxicity by Isorhamnetin: Mechanistic insights into oxidative stress, inflammation, and apoptosis modulation

R Abudalo, O Gammoh, S Altaber, Y Bseiso, E Qnais… - Toxicology Reports, 2024 - Elsevier
The flavonoid compound Isorhamnetin (IRMN) is known for its considerable
pharmacological properties, which include antioxidant and anti-inflammatory effects, as well …

Topical administration of an apoptosis inducer mitigates bleomycin-induced skin fibrosis

MN Huda, EA Borrego, CD Guerena… - ACS Pharmacology & …, 2023 - ACS Publications
Pathological fibrosis is distinguished from physiological wound healing by persistent
myofibroblast activation, suggesting that therapies that induce myofibroblast apoptosis …

EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

R El Hajj, H Bou Youness, L Lachaud… - PLoS neglected …, 2018 - journals.plos.org
Cutaneous Leishmaniasis (CL) is a parasitic infection classified by the WHO as one of the
most uncontrolled spreading neglected diseases. Syria is endemic for Leishmania tropica …