Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The
NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms …

Background Plasma glucose levels are tightly regulated within a narrow physiologic range.
Insulin-mediated glucose uptake by tissues must be balanced by the appearance of glucose …

Pancreatic β-cells couple the oxidation of glucose to the secretion of insulin. Apart from the
canonical K ATP-dependent glucose-stimulated insulin secretion (GSIS), there are important …

Synthesis of phosphoenolpyruvate (PEP) from oxaloacetate is an absolute requirement for
gluconeogenesis from mitochondrial substrates. Generally, this reaction has solely been …

This paper describes the problems of measuring the allosteric ATP-inhibition of cytochrome
c oxidase (CcO) in isolated mitochondria. Only by using the ATP-regenerating system …

Differential 'fuel usage'has been proposed as a mechanism for life-span extension by caloric
restriction (CR). Here, we report the effects of CR, initiated after weaning, on metabolic …

Increased participation of aged individuals in athletics warrants basic research focused on
delineating age-related changes in performance variables. On the basis of potential age …

Sarcopenia is associated with reduced quality of life and premature mortality. The sex
disparities in the processes underlying sarcopenia pathogenesis, which include …

Enhanced hepatic gluconeogenesis plays an important role in exercise glucose
homeostasis when hepatic glycogen stores are depleted. Livers from trained animals …

In response to decreased use, skeletal muscle undergoes an adaptive reductive
remodeling. There is a shift in fiber types from slow twitch to fast twitch fiber types …