Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role
in assisting correct folding and functionality of its client proteins in cells. The Hsp90 client …

Respect for the primary cilium has undergone a remarkable renaissance over the past
decade, and it is now thought to be an essential regulator of numerous signaling pathways …

The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of
spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase …

Centrosomes in animal cells are dynamic organelles with a proteinaceous matrix of
pericentriolar material assembled around a pair of centrioles. They organize the microtubule …

Cilia are small microtubule‐based cellular appendages that are broadly classified as being
either motile or immotile (primary cilia). Since their initial discovery several centuries ago …

The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the
cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive …

Cilia are organelles specialized for movement and signaling. To infer when during evolution
signaling pathways became associated with cilia, we characterized the proteomes of cilia …

Cilia are thought to harbour a membrane diffusion barrier within their transition zone (TZ)
that compartmentalises signalling proteins. How this “ciliary gate” assembles and functions …