The implications of drug-polymer interactions on the physical stability of amorphous solid dispersions

M Bookwala, PLD Wildfong - Pharmaceutical Research, 2023 - Springer
Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Understanding the Influence of API Conformations on Amorphous Dispersion Formation Potential Predictions using the R3m Molecular Descriptor

K DeBoyace, M Bookwala, D Zhou… - Molecular …, 2024 - ACS Publications
The R 3 m molecular descriptor (R-GETAWAY third-order autocorrelation index weighted by
the atomic mass) has previously been shown to encode molecular attributes that appear to …

Solubility data and solubility parameters of barnidipine in different pure solvents

M Peña-Fernández, G Spanò, NS Torres-Pabón… - 2023 - digibug.ugr.es
Introduction: Solubility studies and obtaining physicochemical data on drugs in pure
solvents belonging to different chemical classes are key to developing new drug …

Molecular Modeling in Drug Delivery: Polymer Protective Coatings as Case Study

A Bunker, J Kehrein - … Pharmaceutics: AI and Modeling in Pharma …, 2024 - books.google.com
In this chapter, we discuss the use of the computational technique of molecular dynamics
(MD) simulation as a design tool for the development of polymers as a means to enhance …

Investigation on Hansen Solubility Parameter of Caffeine Dissolved in Different Pure Solvents

MÁ Peña, A Kaproulia, DR Delgado… - Journal of …, 2024 - science.sdpublishers.org
Aims: Solubility is a molecular property decisive in the entire process from drug development
and design to the final drug formulation and production, the main objective of this paper is to …

[HTML][HTML] Solubilidad y parámetros de solubilidad del barnidipino en diferentes disolventes puros

M Peña-Fernández, G Spanò… - Ars Pharmaceutica …, 2023 - SciELO Espana
Introduction: Solubility studies and obtaining physicochemical data on drugs in pure
solvents belonging to different chemical classes are key to developing new drug …