Presumably, intensity-modulated proton radiotherapy (IMPT) is the most powerful form of
proton radiotherapy. In the current state of the art, IMPT beam configurations (ie the number …

High-dimensional optimization is a critical challenge for operating large-scale scientific
facilities. We apply a physics-informed Gaussian process (GP) optimizer to tune a complex …

Objective. Intensity modulated proton therapy (IMPT) is an emerging treatment modality for
cancer. However, treatment planning for IMPT is labour-intensive and time-consuming. We …

Purpose In proton therapy, dose distributions are currently often conformed to organs at risk
(OARs) using the less sharp dose fall‐off at the lateral beam edge to reduce the effects of …

Purpose Our purpose was to compare robust intensity modulated proton therapy (IMPT)
plans, automatically generated with wish-list–based multicriterial optimization as …

Objective. Fully automated beam orientation optimization (BOO) for intensity-modulated
radiotherapy and intensity modulated proton therapy (IMPT) is gaining interest, since …

Each year, approximately 18 million new cancer cases are diagnosed worldwide, and about
half must be treated with radiotherapy. A successful treatment requires treatment planning …

Purpose The aim of this study was to evaluate an automated treatment planning method for
robustly optimized intensity modulated proton therapy (IMPT) plans for oropharyngeal …

Current beam orientation optimization algorithms for radiotherapy, such as column
generation (CG), are typically heuristic or greedy in nature because of the size of the …

Intensity Modulated Radiation Therapy (IMRT) is a widely used radiation therapy technique
to treat cancer. The main goal in IMRT is to obtain a treatment plan that eliminates cancer …