Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Enzymatic-based proximity labeling approaches based on activated esters or phenoxy
radicals have been widely used for mapping subcellular proteome and protein interactors in …

Optogenetics is a technique employing natural or genetically engineered photoreceptors in
transgene organisms to manipulate biological activities with light. Light can be turned on or …

RNA molecules are highly compartmentalized in eukaryotic cells, with their localizations
intimately linked to their functions. Despite the importance of RNA targeting, our current …

Optogenetics has been, and will continue to be, a boon to mechanistic studies of cellular
processes. Genetically encodable proteins that sensitize the production of reactive oxygen …

Monoclonal antibodies are the classical basis for targeted therapy, but the development of
alternative binding proteins has made it possible to use non-immunoglobulin proteins as …

Cell type-specific interfaces within living animals will be invaluable for achieving
communication with identifiable cells over the long term, enabling applications across many …

Developmental biology has been continually shaped by technological advances, evolving
from a descriptive science into one immersed in molecular and cellular mechanisms. Most …

The circuitry of the brain is characterized by cell heterogeneity, sprawling cellular anatomy,
and astonishingly complex patterns of connectivity. Determining how complex neural circuits …