The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling
events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such …

Myosins constitute a large superfamily of actin-dependent molecular motors. Phylogenetic
analysis currently places myosins into 15 classes. The conventional myosins which form …

Physical forces generated by cells drive morphologic changes during development and can
feedback to regulate cellular phenotypes. Because these phenomena typically occur within …

The mechanical microenvironment is known to influence single-cell migration; however, the
extent to which mechanical cues affect collective migration of adherent cells is not well …

The molecular and cellular bases of cell shape change and movement during
morphogenesis and wound healing are of intense interest and are only beginning to be …

Despite considerable efforts to improve early detection, and advances in chemotherapy,
metastasis remains a major challenge in the clinical management of ovarian cancer. Studies …

Directed cell migrations are important for development, but the signaling pathways and
mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration …

Cell movements are essential for animal development and homeostasis but also contribute
to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to …

AMP-activated protein kinase (AMPK, also known as SNF1A) has been primarily studied as
a metabolic regulator that is activated in response to energy deprivation. Although there is …

The conversion of stationary epithelial cells into migratory, invasive cells is important for
normal embryonic development and tumour metastasis. Border-cell migration in the ovary of …