Abstract Nonconjugated hydrocarbons, like bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane,
triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and …

Antimicrobial peptides and their precursor molecules form a central part of human and
mammalian innate immunity. The underlying genes have been thoroughly investigated and …

Antimicrobial resistance has become a critical global health problem due to the abuse of
conventional antibiotics and the rise of multi-drug-resistant microbes. Antimicrobial peptides …

Based on very extensive studies on four peptides (alamethicin, melittin, magainin and
protegrin), we propose a mechanism to explain the cooperativity exhibited by the activities of …

The growing problem of bacterial resistance to conventional antibiotic compounds and the
need for new antibiotics have stimulated interest in the development of antimicrobial …

Infectious disease is a critically important global healthcare issue. In the US alone there are
2 million new cases of hospital-acquired infections annually leading to 90,000 deaths and 5 …

The mechanism of membrane interaction of two amphipathic antimicrobial peptides, MSI-78
and MSI-594, derived from magainin-2 and melittin, is presented. Both the peptides show …

Hydrophobic mismatch is important for pore-forming amphipathic antimicrobial peptides, as
demonstrated recently [Grau-Campistany, A., et al.(2015) Sci. Rep. 5, 9388]. A series of …

Abstract PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides
from frog skin with known synergistic antimicrobial activity. By systematically mutating …

The high-resolution three-dimensional structure of an antimicrobial peptide has implications
for the mechanism of its antimicrobial activity, as the conformation of the peptide provides …