TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to
indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a …

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …

Cancer remains a significant global challenge, and despite the numerous strategies
developed to advance cancer therapy, an effective cure for metastatic cancer remains …

Environmental exposure to urban particulate matter (UPM) is a serious health concern
worldwide. Although several studies have linked UPM to ocular diseases, no study has …

Ethnopharmacological relevance Triple-negative breast cancer (TNBC) represents the most
aggressive subtype of breast cancer, featuring a high proportion of cancer stem cells (CSCs) …

Simple Summary OGG1-enabled NFκB activity can promote cancer progression via a
number of key mechanisms that include phenotypic transitions of cancer and stromal cells …

Here, we have discussed the molecular mechanisms of p53-responsive microRNAs
dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) …

Background Non-small cell lung cancer (NSCLC) has a high mortality rate and poor
prognosis. The early detection of high-risk patients is essential to improve patient prognosis …