Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …

Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies
worldwide and survival has not improved substantially in the past 30 years. Desmoplasia …

There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …

Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for
prevention and treatment are urgently needed. We previously reported that histone H4 …

Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

The mechanisms that regulate mammalian organ size are poorly understood. It is unclear
whether the pathways that control organ size also impinge on stem/progenitor cells. A highly …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often
involves somatic activation of K-Ras oncogenes. We report that selective expression of an …