Telomerase structural biology comes of age
Telomerase is an RNA–protein complex comprising telomerase reverse transcriptase, a non-
coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or …
coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or …
Potential roles of telomeres and telomerase in neurodegenerative diseases
J Wang, Y Liu, Q Xia, Q Xia, B Wang, C Yang… - International journal of …, 2020 - Elsevier
Telomeres, protective DNA-protein complexes at the end of eukaryotic linear chromosomes,
play pivotal roles in the maintenance of genomic stability during cell division. When …
play pivotal roles in the maintenance of genomic stability during cell division. When …
Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP
Summary 7SK non-coding RNA (7SK) negatively regulates RNA polymerase II (RNA Pol II)
elongation by inhibiting positive transcription elongation factor b (P-TEFb), and its …
elongation by inhibiting positive transcription elongation factor b (P-TEFb), and its …
LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis
TL Kao, YC Huang, YH Chen, P Baumann… - Nature …, 2024 - nature.com
Human telomerase assembly is a highly dynamic process. Using biochemical approaches,
we find that LARP3 and LARP7/MePCE are involved in the early stage of human telomerase …
we find that LARP3 and LARP7/MePCE are involved in the early stage of human telomerase …
The Alazami syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness
The La-related protein 7 (LARP7) forms a complex with the nuclear 7SK RNA to regulate
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …
Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7
CD Eichhorn, Y Yang, L Repeta… - Proceedings of the …, 2018 - National Acad Sciences
The La and the La-related protein (LARP) superfamily is a diverse class of RNA binding
proteins involved in RNA processing, folding, and function. Larp7 binds to the abundant long …
proteins involved in RNA processing, folding, and function. Larp7 binds to the abundant long …
LARP7-mediated U6 snRNA modification ensures splicing fidelity and spermatogenesis in mice
X Wang, ZT Li, Y Yan, P Lin, W Tang, D Hasler… - Molecular cell, 2020 - cell.com
U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing
spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most …
spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most …
Structure of LARP7 protein p65–telomerase RNA complex in telomerase revealed by cryo-EM and NMR
Abstract La-related protein 7 (LARP7) are a family of RNA chaperones that protect the 3′-
end of RNA and are components of specific ribonucleoprotein complexes (RNP). In …
end of RNA and are components of specific ribonucleoprotein complexes (RNP). In …
The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme
The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
addition to a reverse transcriptase and an RNA template, telomerase contains additional …
Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW8O30} Determined by Single‐Cell Proteomics Analysis
L Gong, W Ding, Y Chen, K Yu, C Guo… - Angewandte Chemie …, 2021 - Wiley Online Library
The 10‐nuclear heteroatom cluster modified {SbW8O30} was successfully synthesized and
exhibited inhibitory activity (IC50= 0.29 μM). Based on proteomics analysis, Na4Ni2Sb2W2 …
exhibited inhibitory activity (IC50= 0.29 μM). Based on proteomics analysis, Na4Ni2Sb2W2 …