The attention to chiral drugs has been raised to an unprecedented level as drug discovery
and development strategies grow rapidly. However, separation of enantiomers is still a huge …

Replacement of the furanosyl oxygen with a methylene unit in the ribose sugar in
nucleosides 1 and nucleotides 2 prompted the rise of a new nucleoside class with very …

Preferential crystallization can be a highly efficient method of producing enantiopure
chemicals at large scale. While most preferential crystallization processes have been …

The monohydrated co‐crystal composed of the chiral active pharmaceutical ingredient
proxyphylline, salicylic acid, and water was successfully resolved by preferential …

The (R)-and (S)-baclofenium hydrogenomaleate system exhibits an extensive chiral
discrimination in the solid state at room temperature. Nevertheless, above 145° C, the critical …

We here report the first occurrence of a preferential cocrystallization process assisted by
compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid …

The preparative resolution by preferential crystallization (PC) of proxyphylline has been
achieved despite the existence of a stable racemic compound. This is enabled through the …

Chiral resolution by preferential crystallization from a racemic or scalemic solution occurs by
selective crystallization of a single enantiomer as a homochiral solid phase, known as a …

The synthesis, crystal structure and luminescence properties of three cyclometalated Ir (III)
complexes of general formula [(ppy) 2Ir (pam)] X, where X= Cl−(1), PF6−(2), ClO4−(3), and …

Chirality plays a pivotal role in contemporary science as it represents a distinctive feature
found in molecules and crystals. This chapter constitutes an excursion into solid-state …