Sex differences are reported in hippocampal plasticity, cognition, and in a number of
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …

Exercise is a non-pharmacological strategy to mitigate the deleterious effects of aging on
brain health. However, a large amount of variation exists in its efficacy. Sex of participants …

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and
growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity …

Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …

Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …

Experience-dependent plasticity shapes postnatal development of neural circuits, but the
mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are …

Adolescence is a critical period for brain maturation. Deciphering how disturbances to the
central nervous system at this time affect structure, function and behavioural outputs is …

Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous
factors. Here, we review the role of sex hormones in the regulation of adult hippocampal …