Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …

Emerging severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) variants,
especially those of concern, may have an impact on the virus's transmissibility and …

Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …

Many organisms evolved strategies to survive desiccation. Plant seeds protect dehydrated
embryos from various stressors and can lay dormant for millennia. Hydration is the key …

RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …

Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …

P granules and other RNA/protein bodies are membrane-less organelles that may assemble
by intracellular phase separation, similar to the condensation of water vapor into droplets …

Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …